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Synthesis of the degradation product of auromomycin chromophore and DNA-cleaving activities of its derivatives

โœ Scribed by Masayuki Shibuya; Hiromu Sakurai; Toshio Maeda; Eiji Nishiwaki; Masako Saito


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
209 KB
Volume
27
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


The syntheses and metallic ion induced DNA-cleaving activities of the degradation product of antitumor antibiotic auromomycin and its derivatives are described.


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Synthesis of the sulfone containing lo-membered enediyne derivative 3 and its cycloaromatization in basic conditions via an ailenic sulfone intermediate as well as its DNA cleaving activities are described. The new class of antitumor antibiotics calicheamicins,l esperamicins,\* and dynemicin As hav