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Synthesis of the Core Bicyclic System (I) of Hyperforin (II) and Nemorosone (III).

✍ Scribed by George A. Kraus; Tuan H. Nguyen; Insik Jeon


Publisher
John Wiley and Sons
Year
2003
Weight
101 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of the Bicyclic Core of Pumili
✍ Alexander Sudau; Winfried MΓΌnch; Jan-W. Bats; Udo Nubbemeyer πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 240 KB πŸ‘ 1 views

The bicyclic core of the pumiliotoxins was synthesized in nine to eleven steps starting from L-(-)-proline. This chiral pool starting material was initially converted into an optically active 2-vinylpyrrolidine by standard operations. The first key step allowed the generation of a nine-membered ring