Synthesis of the Bicyclic Core of Pumili
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Alexander Sudau; Winfried MΓΌnch; Jan-W. Bats; Udo Nubbemeyer
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Article
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2002
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John Wiley and Sons
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English
β 240 KB
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The bicyclic core of the pumiliotoxins was synthesized in nine to eleven steps starting from L-(-)-proline. This chiral pool starting material was initially converted into an optically active 2-vinylpyrrolidine by standard operations. The first key step allowed the generation of a nine-membered ring