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Synthesis of the civet constituent cis-(6-methyltetrahydropyran-2-yl)acetic acid

✍ Scribed by Bates, Hans Aaron; Deng, Ping Nan


Book ID
120882715
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
442 KB
Volume
48
Category
Article
ISSN
0022-3263

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A Short Synthesis of (Β±)-(cis-6-Methylte
✍ Cornelius Nussbaumer; Georg FrΓ‘ter πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 German βš– 386 KB

Similar cyclizations to tetrahydropyrans are known [lo] to occur when 4-methyl-4-pentcn-2-01 Is condensed with aldehydes under acidic conditions (Kriewitz-Prim reaction [l I]). A /I-alkenyloxyacrylate cyclization has already found use in a stereoselective synthesis of (i)-cis-a-irone [ 161.