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Synthesis of the Carbon Framework of the Stephaoxocanes Employing a Sequential RCM/Pomeranz–Fritsch Approach

✍ Scribed by Andrea B. J. Bracca; Teodoro S. Kaufman

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
218 KB
Volume
2007
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

The syntheses of two cyclodeca[ij]isoquinoline derivatives, which embody the carbon framework of stephaoxocanidine, excentricine and the recently isolated stephalonganines A, B and C, are reported. The target tricyclic compounds were prepared from isovanillin, employing a ring‐closing metathesis approach towards the synthesis of a benzocyclodecane‐type common intermediate; different modifications of thePomeranz–Fritsch protocol allowed the installation of the heterocyclic ring.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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