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Synthesis of the C38–C54 spiroketal segment of halichondrin B

✍ Scribed by J.S. Yadav; C. Nagendra Reddy; G. Sabitha


Book ID
113930651
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
383 KB
Volume
53
Category
Article
ISSN
0040-4039

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Synthetic Studies towards Halichondrins:
✍ Thomas D. Aicher; Keith R. Buszek; Francis G. Fang; Craig J. Forsyth; Sun Ho Jun 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 277 KB

An efficient synthesis of the C.27-C.38 segment of halichondrins is accomplished, using the Ireland-Claisen rearrangement, Ni(ll)lCr(Il)-mediated coupling and Michael reactions as the key steps.