The C29-C44 portion of altohyrtins (spongistatins) has been prepared from 1,5-pentanediol and D-glucose in a stereoselective manner. The convergent synthesis relied on a coupling reaction of the C29-C37 vinyl bromide and the C38-C44 Weinreb amide, diastereoselective reduction of the C38 ketone, and
✦ LIBER ✦
Synthesis of the C29−C44 Portion of Spongistatin 1 (Altohyrtin A)
✍ Scribed by Wallace, Grier A.; Scott, Robert W.; Heathcock, Clayton H.
- Book ID
- 126206619
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 176 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3263
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