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Synthesis of the C29−C44 Portion of Spongistatin 1 (Altohyrtin A)

✍ Scribed by Wallace, Grier A.; Scott, Robert W.; Heathcock, Clayton H.


Book ID
126206619
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
176 KB
Volume
65
Category
Article
ISSN
0022-3263

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The C29-C44 portion of altohyrtins (spongistatins) has been prepared from 1,5-pentanediol and D-glucose in a stereoselective manner. The convergent synthesis relied on a coupling reaction of the C29-C37 vinyl bromide and the C38-C44 Weinreb amide, diastereoselective reduction of the C38 ketone, and

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