Synthesis of the C(1)C(16) fragment of
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Matthew O'Brien; Nicholas H Taylor; Eric J Thomas
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Article
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2002
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Elsevier Science
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French
⚖ 87 KB
A synthesis of the C(1) C( 16) fragment 43 of the bryostatins is reported which features a stereoselective equivalent of an 'ene' reaction between the allylsilane 35 and the alkynone 33 and the stereoselective conjugate addition-cyclisation of the dienyl ketone 36 to give the acetal 39 after acetali