Synthesis of the C(1)C(16) fragment of bryostatins

✍ Scribed by Matthew O'Brien; Nicholas H Taylor; Eric J Thomas

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 87 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01054-7

✦ Synopsis

A synthesis of the C(1) C( 16) fragment 43 of the bryostatins is reported which features a stereoselective equivalent of an 'ene' reaction between the allylsilane 35 and the alkynone 33 and the stereoselective conjugate addition-cyclisation of the dienyl ketone 36 to give the acetal 39 after acetalisation.