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Synthesis of the C-terminal tetrapeptide sequence derived from glucagon

✍ Scribed by H. C. Beyerman; J. S. Bontekoe

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 608 KB
Volume: 81
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19620810809

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✦ Synopsis

Abstract

A synthesis is described of the partially protected carboxyl‐terminal tetrapeptide sequence, L‐leucyl‐L‐methionyl‐L‐asparaginyl‐O‐t‐butyl‐L‐threonine t‐butyl ester, which is derived from the pancreatic hormone glucagon.

In this synthesis we used successfully a novel combination of blocking groups, the t‐butoxy group and t‐butyl ester, together with N‐phthaloyl protection.

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