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Synthesis of the bicyclic core of tagetitoxin

✍ Scribed by Plet, Julien R. H.; Porter, Michael J.


Book ID
120454844
Publisher
Royal Society of Chemistry
Year
2006
Tongue
English
Weight
343 KB
Volume
11
Category
Article
ISSN
1359-7345

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Synthesis of the Bicyclic Core of Pumili
✍ Alexander Sudau; Winfried MΓΌnch; Jan-W. Bats; Udo Nubbemeyer πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 240 KB πŸ‘ 1 views

The bicyclic core of the pumiliotoxins was synthesized in nine to eleven steps starting from L-(-)-proline. This chiral pool starting material was initially converted into an optically active 2-vinylpyrrolidine by standard operations. The first key step allowed the generation of a nine-membered ring