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Synthesis of the BCDE rings of ciguatoxin 1B via an acetylene biscobalthexacarbonyl–vinylsilane strategy

✍ Scribed by Kazunobu Kira; Minoru Isobe

Book ID
104230359
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
188 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A synthetic route to the BCDE rings of ciguatoxin 1B has been explored through acetylene biscobalthexacarbonyl complex and vinylsilane strategy. The key issues in the current synthesis are (i) ether ring cyclization by means of the acetylene cobalt complex and (ii) reductive decomplexation of the product endo-complexes into the corresponding vinylsilanes. A sequential cyclization route is also described along this line.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of the BC
ChemInform Abstract: Synthesis of the BCD-Ring (I) of Ciguatoxin 1B Using an Acetylene Cobalt Complex and Vinylsilane Strategy.
✍ Kazunobu Kira; Akinari Hamajima; Minoru Isobe 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Acetylene cobalt complex and vinylsilane
Acetylene cobalt complex and vinylsilane strategy in the synthesis of ciguatoxin (D)EF analog
✍ Kazunobu Kira; Minoru Isobe 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 234 KB

A synthetic route to the (D)EF analog of ciguatoxin has been explored through acetylene cobalt complex and vinylsilane strategy. The central reactions in the synthesis are: (i) ether ring formation mediated by acetylene cobalt complex and (ii) decomplexation of the endo-acetylene cobalt complexes to