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Acetylene cobalt complex and vinylsilane strategy in the synthesis of ciguatoxin (D)EF analog

✍ Scribed by Kazunobu Kira; Minoru Isobe

Book ID: 104210622
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 234 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00988-6

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✦ Synopsis

A synthetic route to the (D)EF analog of ciguatoxin has been explored through acetylene cobalt complex and vinylsilane strategy. The central reactions in the synthesis are: (i) ether ring formation mediated by acetylene cobalt complex and (ii) decomplexation of the endo-acetylene cobalt complexes to vinylsilanes or ole®ns. Unusual rearrangement of epoxy-silane to allylic alcohol is also described.

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