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Synthesis of the BCDE Molecular Fragment of Azadiradione Mediated by Titanocene(III)

✍ Scribed by Fernández-Mateos, A.; Madrazo, S. Encinas; Teijón, P. Herrero; Clemente, R. Rabanedo; González, R. Rubio; González, F. Sanz


Book ID
121279206
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
892 KB
Volume
78
Category
Article
ISSN
0022-3263

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## Abstract We describe the first synthesis of 3β‐hydroxydihydroconfertifolin (**3**) and 3β‐hydroxycinnamolide (**4**), together with improved procedures for the preparation of other 3‐hydroxydrimanes (**2** and **5**) scarce in nature. The key step was the titanocene(III)‐promoted cyclization of