## Abstract We describe the first synthesis of 3β‐hydroxydihydroconfertifolin (**3**) and 3β‐hydroxycinnamolide (**4**), together with improved procedures for the preparation of other 3‐hydroxydrimanes (**2** and **5**) scarce in nature. The key step was the titanocene(III)‐promoted cyclization of
Total Synthesis of 3-Hydroxydrimanes Mediated by Titanocene(III) — Evaluation of Their Antifeedant Activity.
✍ Scribed by Jose Justicia; J. Enrique Oltra; Alejandro F. Barrero; Ana Guadano; Azucena Gonzalez-Coloma; Juan M. Cuerva
- Book ID
- 101975714
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 18 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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A simple and highly efficient method has been developed for the synthesis of 3,3-diindolyl oxyindoles by the reaction of indoles with isatin or 5-fluoro isatin using a catalytic amount (5 mol%) of FeCl(3) at room temperature in a short reaction time in high yields. All these compounds were evaluated