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Synthesis of the BCD-Ring Substructure of Granaticin A

✍ Scribed by Bachmann, Janina; Mang, Christian; Haustedt, Lars Ole; Harms, Klaus; Koert, Ulrich


Book ID
118235820
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
536 KB
Category
Article
ISSN
1434-193X

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Reaction of Grignard reagents with bispidine-derived N-acyliminium ions (generated in situ from an amethoxy bispidine amide) has been studied as a new route to sparteine analogues. The addition reactions proceed with complete diastereoselectivity to generate products with the same relative stereoche