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Synthesis of the aziridino[1,2-a]pyrrolidine substructure of the antitumor agents azinomycin A and B

โœ Scribed by Coleman, Robert S.; Carpenter, Andrew J.

Book ID
124057923
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
422 KB
Volume
57
Category
Article
ISSN
0022-3263

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๐Ÿ“œ SIMILAR VOLUMES

The development of strategies for constr
The development of strategies for construction of the aziridine core of the antitumor agents azinomycins A and B
โœ Robert S. Coleman; Andrew J. Carpenter ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 780 KB

The synthesis of the C6-C 13 aziridino [ 1,2a]pyrrolidine core substructure of the antitumor agents azinomycins A (la) and B (lb) is described. Key synthetic steps included Wadsworth-Horner-Emmons olefination for formation of the C7-C8 double bond, an E-selective electrophilic bromination of the C8

ChemInform Abstract: The Development of
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โœ R. S. COLEMAN; A. J. CARPENTER ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 2 views

The Development of Strategies for Construction of the Aziridine Core of the Antitumor Agents Azinomycins A and B. -The key steps in the synthesis of the aziridine (VII) are Wadsworth-Horner-Emmons olefination to form the derivative (III), its bromination to the (E)-isomer (IV), and cyclization of th