✦ LIBER ✦

Synthesis of the [3H] labelled potent and selective peripheral benzodiazepine receptor ligand CB 34

✍ Scribed by A. Latrofa; G. Trapani; M. Franco; M.J. Harris; M. Serra; G. Biggio; G. Liso

Publisher: John Wiley and Sons
Year: 2001
Tongue: French
Weight: 104 KB
Volume: 44
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.481

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✦ Synopsis

Abstract

The synthesis of the [^3^H] labelled peripheral benzodiazepine receptor (PBR) ligand CB 34, useful for binding assay, tissue distribution studies, and elucidation of the physiological role of PBR, is described. Catalytic reduction with ^3^H~2~ gas and 10% Pd/C catalyst of the key intermediate 2 afforded the product at a specific activity of 111 Ci/mmol. Copyright © 2001 John Wiley & Sons, Ltd.

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