Synthesis of the 3′-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3′-S-phosphorothiolate linkage
✍ Scribed by Gaynor, James W; Bentley, Joanne; Cosstick, Richard
- Book ID
- 109946380
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 292 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1750-2799
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## Eflcient procedures are described for the synthesis of dinucleoside phosphorothiolates using either a Michaelis-Arburov-type reaction or a phosphotriester approach. The utility of backbone-modified polynucleotides in molecular biology192 and as potential therapeutic drugs2" makes such compounds