𝔖 Bobbio Scriptorium
✦   LIBER   ✦

New methods for the synthesis of 3′-S-phosphorothiolate internucleoside linkages

✍ Scribed by Joseph S. Vyle; Xiang Li; Richard Cosstick

Book ID
104216068
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
237 KB
Volume
33
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Eflcient procedures are described for the synthesis of dinucleoside phosphorothiolates using either a Michaelis-Arburov-type reaction or a phosphotriester approach.

The utility of backbone-modified polynucleotides in molecular biology192 and as potential therapeutic drugs2" makes such compounds targets of considerable interest. DNA analogues in which sulphur is substituted for oxygen in the phosphodiester linkages are minimally perturbed from the natural structure5*6 and in the case of 3'&phosphorothiolates7 avoid problems associated with an asymmetric phosphorus centre. We have previously

📜 SIMILAR VOLUMES

ChemInform Abstract: Solid-Phase Synthes
ChemInform Abstract: Solid-Phase Synthesis of Oligodeoxynucleotides Containing 3′-S-Phosphorothiolate Linkages
✍ Kevin J. Fettes; Ian O'Neil; Stanley M. Roberts; Richard Cosstick 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v