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Synthesis of the 2,3-dihydro-6H-1,4-oxazin-2-ones chiral at C(3) and asymmetric induction in hydrogenation of the azomethine bond

✍ Scribed by Caplar, Vesna; Lisini, Adriana; Kajfez, Franjo; Kolbah, Dragutin; Sunjic, Vitomir


Book ID
121361681
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
652 KB
Volume
43
Category
Article
ISSN
0022-3263

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Asymmetric Synthesis of the cis- and tra
✍ Emmanuel CouchΓ©; Abdellatif Fkyerat; Raffaele Tabacchi πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 German βš– 165 KB

## Abstract A short and efficient protocol for the asymmetric synthesis of __cis__‐ and __trans__‐3,4‐dihydro‐2,4,8‐trihydroxynaphthalen‐1(2__H__)‐one (**1** and **2**, resp.) is described, with a phthalide annulation as the key step. Introduction of a OH substituent at position 2 was performed by