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Synthesis of the (1S,2S)- and (1R,2S)-stereoisomers of the respective E- and Z-isomers of ethyl 4-[(2-hydroxycyclohexyl)methyl]phenoxy-3-methyl-2-butenoate using yeast whole cell bioreduction of the parent ketones

✍ Scribed by Zdeněk Wimmer; David Šaman; Marie Zarevúcka; Martina Wimmerová


Book ID
108283979
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
160 KB
Volume
16
Category
Article
ISSN
0957-4166

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Optically pure L-armentomycin t(S)-2-amino-4,4-dichlorobutanoic acid] and its D-isomer [(R)-2-amino-4,4-dichlorobutanoic acid] were prepared by using methyl (E)-and (Z)-2,4,4-trichloro-2-butenoate as key intermediate, which were reduced with baker's yeast to (R)-and (S)-2,4,4-trichlorobutanoate in 8