✦ LIBER ✦
A facile synthesis of optically pure L-armentomycin and its D-isomer.Highly enantioselective reduction of the CC double bond of methyl (E)- and (Z)-2,4,4-trichloro-2-butenoate by using baker's yeast
✍ Scribed by Masanori Utaka; Satoshi Konishi; Toshiyasu Okubo; Sadao Tsuboi; Akira Takeda
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 192 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Optically pure L-armentomycin t(S)-2-amino-4,4-dichlorobutanoic acid] and its D-isomer [(R)-2-amino-4,4-dichlorobutanoic acid] were prepared by using methyl (E)-and (Z)-2,4,4-trichloro-2-butenoate as key intermediate, which were reduced with baker's yeast to (R)-and (S)-2,4,4-trichlorobutanoate in 84-92 and 97-98% ee, respectively, in 60-65% yields.