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Synthesis of the 15N-labelled insecticide imidacloprid

✍ Scribed by Nicole Schippers; Wolfgang Schwack

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
97 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A five‐step synthesis of the neonicotinoid insecticide imidacloprid (1) labelled with ^15^N is reported in an overall yield of 10%. The stable isotope ^15^N was introduced in the pyridine part by reaction of ^15^NH~3~ with coumalic acid methyl ester (2) to ^15^N‐hydroxy nicotinic acid (3) followed by further reactions to ^15^N‐2‐chloro‐5‐(chloromethyl) pyridine (6) which was coupled with N‐nitroimidazolidin‐2‐imine to yield 1. Copyright © 2006 John Wiley & Sons, Ltd.

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