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Synthesis of tetrazole analogs of α-amino acids by alkylation of a Schiff base of α-aminomethyltetrazole

✍ Scribed by Yoshitaka Satoh; Stéphane De Lombaert; Nicholas Marcopulos; John Moliterni; Michael Moskal; Jenny Tan; Eli Wallace

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 199 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00492-4

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✦ Synopsis

A benzophenone imine of N-1 protected ct-aminomethyltetrazoles was found to undergo alkylation with organic halide:; in good yields. Deprotection afforded tetrazole analogs of a-amino acids.

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