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Synthesis of Tetrahydropyrido[2,3-b]pyrazine Scaffolds from 2,3,5,6-Tetrafluoropyridine Derivatives.

✍ Scribed by Christopher A. Hargreaves; Graham Sandford; Rachel Slater; Dmitrii S. Yufit; Judith A. K. Howard; Antonio Vong


Publisher
John Wiley and Sons
Year
2007
Weight
31 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract The synthesis of the title compounds was achieved using the key intermediate ethyl 4,6‐dimethyl‐3‐(pyrrol‐1‐yl)thieno[2,3‐__b__]pyridine‐2‐ carboxylate 2. This latter compound was obtained __via__ the interaction of the thienopyridine amino ester 1 with 2,5 dimethoxytetrahydrofuran in a