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Synthesis of Tertiary β-Hydroxy Amides by Enolate Additions to Acylsilanes

✍ Scribed by Lettan, Robert B.; Reynolds, Troy E.; Galliford, Chris V.; Scheidt, Karl A.


Book ID
127274759
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
58 KB
Volume
128
Category
Article
ISSN
0002-7863

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A highly efficient and stereoselective protocol for the TiCl 4 -mediated addition of organocerium reagents to b-keto amides is now available. The method allows the introduction of a large variety of carbon frameworks, including primary, secondary and tertiary alkyl chains, as well as aromatic, alkyn