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Synthesis of symmetrical dimeric N,N′-linked peptides on solid support by olefin metathesis

✍ Scribed by Kilian Conde-Frieboes; Stina Andersen; Jens Breinholt

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 70 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01637-3

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✦ Synopsis

A method has been developed for the synthesis of dimeric ligands of biological relevance on solid support using olefin metathesis as a key step. With the ruthenium catalyst used, the size of the peptide fragment did not influence the reaction. If the double bond involved was separated by at least 2 methylene groups from an amide group, products of good purity could be recovered.

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