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Synthesis of symmetrical 4,4′- and 6,6′- bis(D-glucose)-based probes as tools for the study of D-glucose transport proteins

✍ Scribed by Mehdi Abbadi; Geoffrey D. Holman; Christophe Morin; William D. Rees; Jing Yang

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 242 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01241-1

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✦ Synopsis

Two glucose moieties have been linked from positions -4 or -6 and hydrophobic groups have been placed symmetrically between the hexose moities. To orossiink glucose and obtain 6,6'-probes, advantage has been taken of the unusual reactivity of D-glucurono-,t-lactone with amines. To obtain 4,4'linked probes, crosslinking via reductive amination has been used. The affinities of these probes for the glucose carrier have bern determined and found to be 20 to 200 times that of D-glucose~

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