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Synthesis of sulfur and nitrogen analogues of monooxo crown ethers

✍ Scribed by Kenji Matsushima; Yohji Nakatsuji; Norio Kawamura; Mitsuo Okahara


Book ID
112128135
Publisher
Journal of Heterocyclic Chemistry
Year
1986
Tongue
English
Weight
180 KB
Volume
23
Category
Article
ISSN
0022-152X

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Nitrogen and sulfur analogues of the sec
✍ M. Tercel; W.A. Denny; W.R. Wilson πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 282 KB

The first synthesis of seco-CI alkylating agents bearing a nitrogen or sulfur substituent in place of the oxygen at C-6 is described. In comparison with a phenol, an amino substituent confers reduced but significant cytotoxicity, even when mono-or dimethylated, while sulfur analogues are considerabl