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Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors

โœ Scribed by Wong, Jessica H. ;Sahni, Urvashi ;Li, Yanhong ;Chen, Xi ;Gervay-Hague, Jacquelyn


Book ID
118262313
Publisher
Royal Society of Chemistry
Year
2009
Tongue
English
Weight
132 KB
Volume
7
Category
Article
ISSN
1477-0520

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Syntheses of some sialic acid-containing nucleotide sugars are reported. The reaction of methyl [(2-hydroxy)ethyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-alpha-D-galacto -2-nonulopyranosid]onate (4) with various fully protected hydrogen phosphonates of nucleosides (5a-c) in the pres