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Synthesis of Novel Mimetics of CMP-Sialic Acid as the Inhibitors of Sialyltransferases.

✍ Scribed by Toru Tanaka; Machiko Ozawa; Tsuyoshi Miura; Toshiyuki Inazu; Shuichi Tsuji; Tetsuya Kajimoto

Publisher
John Wiley and Sons
Year
2003
Weight
231 KB
Volume
34
Category
Article
ISSN
0931-7597

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New Potent Sialyltransferase Inhibitorsβ€”
New Potent Sialyltransferase Inhibitorsβ€”Synthesis of Donor and of Transition-State Analogues of Sialyl Donor CMP-Neu5Ac
✍ Franz Amann; Christoph Schaub; Bernd MΓΌller; Richard R. Schmidt πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 286 KB πŸ‘ 1 views

Enzymatic sialyl transfer with CMP-Neu5Ac as donor can be inhibited by CDP. Therefore phosphonates 1 a,b, 2 and 3 were synthesized as substrate analogues. With a(2 Β± 6)-sialyltransferase from rat liver (EC 2.4.99.1) only moderate inhibition was found for these compounds. In order to obtain transitio