Synthesis of a potent β-lactamase inhibi
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Yuhpyng L. Chen; Chi-Wu Chang; Kirk Hedberg
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Article
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1986
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Elsevier Science
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French
⚖ 217 KB
Dioxo-6-(2-pyridyl)methylenepenicillanic acid (6) was prepared and found to be a potent p-lactamase inhibitor. Its reaction with sodium methoxide was studied to provide insight into its mechanism of enzyme inactivation.