Synthesis of substituted (α-methylene lactams by rhodium catalysed carbonylation of acetylenic amines

✍ Scribed by Eva M. Campi; J.Michael Chong; W.Roy Jackson; Marcel Van Der Schoot

• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 729 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)86969-6

✦ Synopsis

Reactions of y-and P-aminoalkynes, (2) and ( 5) with hydrogen and carbon monoxide in the presence of rhodium catalysts give substituted a-methylene-2-piperidinones (7) and 2-pyrrolidinones (11).