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Synthesis of α,β-unsaturated lactams by palladium-catalysed intramolecular carbonylative coupling

✍ Scribed by Geoffrey T. Crisp; Adam G. Meyer


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
686 KB
Volume
51
Category
Article
ISSN
0040-4020

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ChemInform Abstract: Palladium-Catalyzed
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Palladium-Catalyzed Intramolecular Alkyne-α,β-Unsaturated Carbonyl Coupling. A Formal Synthesis of (+)-Pilocarpine. -Pd-catalyzed enyne coupling of (E) or (Z) alkynoates (I) or (III) provides the alkenyl substituted lactones (II) highly stereoselectively. After esterification with (+)-dimethyltart