Synthesis of substituted anilino-[3-rnethoxy-4-(4-arylthiosemicarbazidocarbonylmethyleneoxy)]benzylidenes: Correlation between anticonvulsant activity and monoamine oxidase inhibitory and antihemolytic properties

✍ Scribed by C. Dwivedi; Raymond D. Harbison; B. Ali; Surendra S. Parmar

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 501 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600630719

✦ Synopsis

Several substituted anilino-[3-methoxy-4-(4-arylthiosemicarbazidocarbonylmethyleneoxy)]benzylidenes were synthesized and characterized by their sharp melting points, elemental analyses, and IR spectra. Their ability to inhibit monoamine oxidase and to afford protection against hypoosmotic hemolysis in dog erythrocytes was found to bear no relationship with their anticonvulsant activity against pentylenetetrazol-induced seizures in mice.

Keyphrases

Anilino-[3-methoxy-4-(4-arylthiosemicarbazidocarbonylmethyleneoxy)]benzylidenes, substituted-synthesis, characterization, monoamine oxidase, antihemolytic, and anticonvulsant activity Anticonvulsant activity-substituted benzylidenes, relationship to monoamine oxidase inhibitory and antihemolytic activity Antihemolytic activity-substituted benzylidenes against hypoosmotic hemolysis, relationship between monoamine oxidase inhibitory activity-substituted benzylidenes, relationship between antihemolytic and anticonvulsant activity 'Analyses for carbon, hydrogen, and nitrogen were performed by the Central Drug Research Institute, Lucknow, India. Melting points were taken in open capillary tubes and are uncorrected.