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Synthesis of Substituted 7,7-Dialkyl-5-chromanones and Related Compounds, New Potassium Channel Activator.

✍ Scribed by Emad M. El-Telbani


Publisher
John Wiley and Sons
Year
2007
Weight
33 KB
Volume
38
Category
Article
ISSN
0931-7597

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Thioalkylation of Enolates, III. Stereos
✍ Groth, Ulrich ;Köhler, Thomas ;Taapken, Thomas 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB

## Abstract α‐Alkylation of the α,β‐unsaturated ketone 1 at C‐4 has been achieved by thioalkylation of the corresponding zinc dienolate with α‐chlorosulfides of type 2. The desulfurization of the β‐(phenylthio) ketones 4 leads directly to the 4‐substituted hexahydroinden‐5‐ones 5. magnified image