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Synthesis of substituted 4-(1H-indol-6-yl)-1H-indazoles as potential PDK1 inhibitors

โœ Scribed by Brzozowski, Martin; O'Brien, Nathan J.; Wilson, David J.D.; Abbott, Belinda M.


Book ID
121377369
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
443 KB
Volume
70
Category
Article
ISSN
0040-4020

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Regiospecific synthesis of 5-(1H-indol-2
โœ Reddeppareddy Dandu; Ming Tao; Kurt A. Josef; Edward R. Bacon; Robert L. Hudkins ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 286 KB

## Abstract magnified image A regiospecific approach to each __N__โ€methylโ€5โ€(1__H__โ€indolโ€2โ€yl)โ€6,7โ€dihydroโ€2__H__โ€indazole isomer is reported. The 1โ€methyl isomer **1** was prepared from 5โ€bromoโ€1โ€methylโ€6,7โ€dihydroโ€1__H__โ€indazole **3** and indoleโ€2โ€boronate **5** by palladium catalyzed Suzuki c