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Synthesis of substituted 3-pyrrolidinecarbonitriles

✍ Scribed by Hiroshi Maruoka; Fumi Okabe; Kenji Yamagata

Book ID: 102338270
Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 211 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440131

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✦ Synopsis

Abstract

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Cyclopropanes substituted at the same ring carbon by two electron‐withdrawing groups such as alkoxycarbonyl or cyano group react with the primary arylamines via a ring‐opening reaction and ensuing intramolecular cyclization to form substituted pyrrolidines.

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