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Synthesis of Substituted 3-Hydroxy-1H,5H-pyrido[1,2-a]-benzimidazol-1-ones as Possible Antimicrobial and Antineoplastic Agents

✍ Scribed by Farid S. G. Soliman; Samia M. Rida; El-Sayed A. M. Badawy; Thomas Kappe


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
382 KB
Volume
317
Category
Article
ISSN
0365-6233

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5(4H)-ones / 2-Chloro-N-cyanomethyl-N-methylnicotinamide / Aromatic nucleophilic substitution A new synthesis of pyrido[3,2-f][1,4]thiazepine derivatives 3 starting with 2-chloronicotinic acid (1), methylaminoacetonitrile hydrochloride and carbon disulfide is described. As proved by a crystal struct