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Synthesis of Substituted 3-Anilino-5-phenyl-1,3-dihydro- 2H-1,4-benzodiazepine-2-ones and their Evaluation as Cholecystokinin-Ligands

✍ Scribed by Michael Offel; Pornthip Lattmann; Harjit Singh; D. C. Billington; Yodchai Bunprakob; Jintana Sattayasai; Eric Lattmann

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
1005 KB
Volume
339
Category
Article
ISSN
0365-6233

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Synthesis of Substituted 3-Anilino-5-phe
Synthesis of Substituted 3-Anilino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-ones and Their Evaluation as Cholecystokinin-Ligands.
✍ Michael Offel; Pornthip Lattmann; Harjit Singh; D. C. Billington; Yodchai Bunpra πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons βš– 22 KB πŸ‘ 1 views

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## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des