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ChemInform Abstract: 1-Phenyl-4(1H)-quinazolinones and 2,3-Dihydro-1-phenyl-4(1H)- quinazolinones as Potential Cholecystokinin Receptor Ligands.

✍ Scribed by G. PENTASSUGLIA; B. BERTANI; D. DONATI; A. URSINI

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

1-Phenyl-4(1H)-quinazolinones and 2,3-Dihydro-1-phenyl-4(1H)quinazolinones as Potential Cholecystokinin Receptor Ligands.

-With a view to their potentially interesting pharmacological activities the title compounds such as (VI), (IX), and (XI) are prepared. These structures show a good overlap in a computer modeling study with a known compound. Among all obtained derivatives compound ( VI) shows a moderate affinity towards the cholecystokinin-B receptor, whereas in the other series such as compound (IXa) a weak but higher affinity towards the cholecystokinin-A receptor is generally observed. -(

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