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Synthesis of sterically-hindered peptidomimetics using 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride

✍ Scribed by Wen-Chung Shieh; Zhuoliang Chen; Song Xue; Joe McKenna; Run-Ming Wang; Kapa Prasad; Oljan Repič

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
181 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

Our study demonstrated that 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride (DMTMM) is a versatile coupling reagent for the synthesis of sterically-hindered peptidomimetics. It is superior to HBTU/HOBt and CDMT in controlling racemization and N-arylation, respectively.

📜 SIMILAR VOLUMES

Synthesis and characterization of 4-(4,6
Synthesis and characterization of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride
✍ Munetaka Kunishima; Chiho Kawachi; Fumiaki Iwasaki; Keiji Terao; Shohei Tani 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 209 KB

4-(4,6-Dimethoxy-l,3,5-triazin-2-yl)-4-methylmotpholinium chloride (DMTMM) was quantitatively synthesized by the coupling of 2-chloro-4,6-dimethoxy-13,5-uiazine and N-methylmorpholine in THF, and fully characterized. Condensation of carboxylic acids and amines by DMTMM proceeded effectivdy in THF to

ChemInform Abstract: 4-(4,6-Dimethoxy-1,
ChemInform Abstract: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium Chloride: An Efficient Condensing Agent Leading to the Formation of Amides and Esters.
✍ Munetaka Kunishima; Chiho Kawachi; Jun Morita; Keiji Terao; Fumiaki Iwasaki; Sho 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views

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