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Synthesis and characterization of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

โœ Scribed by Munetaka Kunishima; Chiho Kawachi; Fumiaki Iwasaki; Keiji Terao; Shohei Tani

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
209 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

4-(4,6-Dimethoxy-l,3,5-triazin-2-yl)-4-methylmotpholinium chloride (DMTMM) was quantitatively synthesized by the coupling of 2-chloro-4,6-dimethoxy-13,5-uiazine and N-methylmorpholine in THF, and fully characterized. Condensation of carboxylic acids and amines by DMTMM proceeded effectivdy in THF to give the corresponding amides in good yield.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of sterically-hindered peptido
Synthesis of sterically-hindered peptidomimetics using 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride
โœ Wen-Chung Shieh; Zhuoliang Chen; Song Xue; Joe McKenna; Run-Ming Wang; Kapa Pras ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 181 KB

Our study demonstrated that 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride (DMTMM) is a versatile coupling reagent for the synthesis of sterically-hindered peptidomimetics. It is superior to HBTU/HOBt and CDMT in controlling racemization and N-arylation, respectively.