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Synthesis of stable prostacyclin analogues

✍ Scribed by G. Galambos; V. Simonidesz; J. Ivanics; K. Horvárth; G. Kovács

Book ID
108381874
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
238 KB
Volume
24
Category
Article
ISSN
0040-4039

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✍ C.W. Bird; H.I. Butler; M.P.L. Caton; E.C.J. Coffee; C.J. Hardy; T.W. Hart; H.J. 📂 Article 📅 1985 🏛 Elsevier Science 🌐 French ⚖ 203 KB

The synthesis is described of (fi)-6a-oxo-6,9-methano-L5-hydroxyprosta-5,13-dienoic acids as stable analogues of prostacyclin with blood platelet aggregation inhibiting activity. Considerable effort has been devoted to the preparation of chemically stable analogues prostacyclin.' We report here the