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Synthesis of Spiro 1,4-Dihydropyridines by Acylation of Heterocyclic Enamines with Isonicotinoyl Chloride.

โœ Scribed by T. T. Kucherenko; V. N. Kisel; R. M. Gutsul; V. A. Kovtunenko


Publisher
John Wiley and Sons
Year
2004
Weight
71 KB
Volume
35
Category
Article
ISSN
0931-7597

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The reactiom of enamina (la-b, 4, 6 ) with fluorinated acyl chlorida (2.4) produced fluorinated 1,3-diketona (3a-O and 1,3-keto-aldehyda (7a-c) in good yieldr M well M byproductr fluorinated acykmida ((k-c). It ir pro& that the resctionm involve nuckophilic attack by the Catom and/or N-atom of the e