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Synthesis of some trifluoromethyl substituted 1-methylpyrazoles

✍ Scribed by James W. Pavlik; Theppawut Israsena Na Ayudhya; Supawan Tantayanon

Book ID: 102341919
Publisher: Journal of Heterocyclic Chemistry
Year: 2003
Tongue: English
Weight: 33 KB
Volume: 40
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570400619

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✦ Synopsis

Abstract

The major products from the reaction of β‐alkoxyvinyl trifluoromethyl ketones 1a‐c with methylhydrazine (2) in absolute ethanol are the 3‐(trifluoromethyl)‐substituted‐1‐methylpyrazoles 3a‐3c with lesser amounts of the 5‐(trifluoromethyl)‐substituted products 4a‐4c and 5a‐5c. Carrying out the reaction in non‐polar, aprotic solvents can further enhance the regioselectivity favoring the 3‐ (trifluoromethyl) ‐substituted isomers.

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