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Synthesis of some substituted 5H-dibenz[b,f]azepines as potential antimalarials

✍ Scribed by Varma, Rajendra S.; Whisenant, L. K.; Boykin, David W.

Book ID
127152847
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
191 KB
Volume
12
Category
Article
ISSN
0022-2623

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Reactions of 5-carboxamido-5H-dibenz[bflazepines (la-ld) with glyoxylic acid methylester methyl hemiacetal (GMHA) led to 5-(carboxamido-N-a-hydroxy-acetic acid methyl ester)-5Hdibenz[b,Aazepines (2a-2d). The reactions with glycols yielded the oligoethylene glycol derivatives (3,4). The new compounds