Dibenz[b,f]azepines, Part 7[1]: Synthesis of New, Potentially CNS Active Dibenz[b,f]azepine Derivatives

✍ Scribed by Ferenc Haász; Zoltán Tóth; Vilmos Galamb

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 315 KB
• Volume: 329
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.19963291207

✦ Synopsis

Reactions of 5-carboxamido-5H-dibenz[bflazepines (la-ld) with glyoxylic acid methylester methyl hemiacetal (GMHA) led to 5-(carboxamido-N-a-hydroxy-acetic acid methyl ester)-5Hdibenz[b,Aazepines (2a-2d). The reactions with glycols yielded the oligoethylene glycol derivatives (3,4). The new compounds were screened as anticonvulsants andor antidepressants (AD).