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Synthesis of Some Ribose-Alkylated 5′-UMP Derivatives

✍ Scribed by Khan, Khurshid Alam ;Qudrat-e-Khuda, M. ;Fizza, Kaniz ;Ahmad, Viqar Uddin

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
365 KB
Volume
1992
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The reaction of 5′‐UMP (1) with methyl, ethyl, n‐propyl, and isopropyl iodide under strongly alkaline conditions gave predominantly ribose‐alkylated derivatives 2–11. The structures of the products have been assigned by using UV spectroscopy, paper electrophoresis, ^1^H‐NMR spectroscopy and fast‐atom bombardment mass spectrometry in the negative ion mode.

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